CHLORAMINE T REAGENT (ACS)
Chloramine-T sodium salt trihydrate
CAS: 7080-50-4
Molecular Formula: C7H11ClNNaO3S
CHLORAMINE T REAGENT (ACS) - Names and Identifiers
| Name | Chloramine-T sodium salt trihydrate |
| Synonyms | CHLORAMINE T 3-HYDRATE Chloroamine t trihydrate Chloramine T sodium salt Chloramine-T, Sodium salt CHLORAMINE T REAGENT (ACS) chloramine-t trihydrate, acs Chloramine-T sodium salt trihydrate N-Chloro-p-toluenesulfonamide, sodium salt N-Chloro-p-toluenesulphonamide sodium salt trihydrate N-Chloro-p-toluenesulfonamide sodium salt, Chloraminum Benzenesulfonamide, N-chloro-4-methyl-, sodium salt, trihydrate |
| CAS | 7080-50-4 |
| EINECS | 615-172-8 |
| InChI | InChI=1/C7H8ClNO2S.Na.3H2O/c1-6-2-4-7(5-3-6)12(10,11)9-8;;;;/h2-5,9H,1H3;;3*1H2/q;+1;; |
CHLORAMINE T REAGENT (ACS) - Physico-chemical Properties
| Molecular Formula | C7H11ClNNaO3S |
| Molar Mass | 247.67 |
| Density | 1.43 |
| Melting Point | 167-170°C(lit.) |
| Flash Point | 92 °C |
| Water Solubility | Soluble in water and ethyl alcohol. Insoluble in benzene and ethers. |
| Solubility | Soluble in water, almost insoluble in benzene, chloroform and ether. |
| Appearance | White or yellow microstrip columnar crystalline powder |
| Color | White to off-white |
| Odor | Chlorine like |
| Merck | 14,2075 |
| BRN | 3924168 |
| pKa | pK1:4.54(+1) (25°C) |
| PH | 8-10 (50g/l, H2O, 20℃) |
| Storage Condition | Store at +2°C to +8°C. |
| Sensitive | Moisture Sensitive |
| MDL | MFCD00000522 |
| Use | Preservatives |
| In vitro study | Gram-positive growth is reduced by 95% to 100% after tosylchloramide treatment, regardless of dose, with or without serum. E coli (gram-negative; with/without serum) is reduced 94% to 100% at antiseptic concentrations of 300 and 400 ppm. At 200 ppm, E coli growth is fully inhibited without serum present and by 50% with serum. At 100 and 200 ppm, cell viability remains greater than 90% under all experimental conditions. A 300-ppm, 3-minute exposure to tosylchloramide results in cell viability of up to 70%, with longer exposures producing lower viabilities. Serum does not affect cell viability in any condition. |
| In vivo study | A dose-dependently significant DNA damage in the rat tissues and inflammation is histopathologically noted around the terminal airways of the lung in both male and female rats. The 24-h exposure to 50 mg/L of chloramine-T is toxic for crayfish and leads to substantial loss of energy that became apparent during subsequently conducted physical stress. Tosylchloramide may potentiate the toxicity of many xenobiotics via metabolic activation and/or accumulation of reactive metabolites. The activities of CYP2E1, CYP1A1/2 CYP2B1/2, CYP3A4 and CYP4A1/2 enzymes significantly increase after treatment with 2.50, 5 and 10 mg/kg bw/day tosylchloramide, in a dose-dependent manner. This effect is not observed after tosylchloramide treatment at dose of 1.25 mg/kg bw/day. |
CHLORAMINE T REAGENT (ACS) - Risk and Safety
| Hazard Symbols | C - Corrosive |
| Risk Codes | R22 - Harmful if swallowed R31 - Contact with acids liberates toxic gas R34 - Causes burns R42 - May cause sensitization by inhalation |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S7 - Keep container tightly closed. |
| UN IDs | UN 3263 8/PG 3 |
| WGK Germany | 2 |
| RTECS | XT5616800 |
| TSCA | Yes |
| HS Code | 29350090 |
| Hazard Class | 8 |
| Packing Group | III |
| Toxicity | LD50 orally in Rabbit: 935 mg/kg |
CHLORAMINE T REAGENT (ACS) - Nature
Open Data Verified Data
white crystalline powder, with slight chlorine odor; Bitter taste. Slow decomposition in air, gradually lose oxygen and become yellow. Valid for 23% ~ 26%, the melting point of 167~170 deg C (decomposition). Soluble in water, soluble in ethanol, glycerol, insoluble in chloroform, ether and benzene. Slowly decompose in water and ethanol, and decompose vigorously in acidic medium, releasing oxygen. When the aqueous solution is buffered to pH 9, it is more stable. The anhydrate exploded at 175-180 °c. It does not decompose when dried at 90-100 °c.
Last Update：2025-06-10 22:55:16
CHLORAMINE T REAGENT (ACS) - Preparation Method
Open Data Verified Data
p-Toluenesulfonyl chloride was aminated to form p-toluenesulfonamide, and then chlorinated with sodium hypochlorite solution.
Last Update：2022-01-01 09:29:14
CHLORAMINE T REAGENT (ACS) - Introduction
Used as a substitute for iodine and hypochlorite standard solutions in volumetric analysis. Verification of bromate and halogen. Determination of iodide, thallium and tin.
Last Update：2022-10-16 17:28:06
CHLORAMINE T REAGENT (ACS) - Application
Open Data Verified Data
It is used as a bactericidal algicide for industrial water treatment, and can be used in combination with its bactericide. Prepared into 0. 0004% aqueous solution for Disinfection treatment, 1%~ 2% solution can be directly administered. In addition, it is used as a bleaching agent in the printing and dyeing industry, mainly for the bleaching of plant fibers and rayon and other fabrics, and can also be used as an oxidative Desizing agent for cotton.
Last Update：2025-08-19 16:24:40
CHLORAMINE T REAGENT (ACS) - Safety
Open Data Verified Data
The effect of mucosal stimulation is small, and the central nervous system function is inhibited by inhalation, and asthma symptoms occur. Storage and transportation should avoid light, stored in a cool place, rain-proof, moisture-proof, sunscreen, not with organic contact.
Last Update：2025-06-10 22:55:16
CHLORAMINE T REAGENT (ACS) - Reference Information
| pH range of acid-base indicator discoloration | 8 - 10 |
| biological activity | tosylchloride sodium trihydrate (Chloramine T sodium trihydrate) is a wide range of disinfectants in the kitchen, laboratory and hospital. It is also used as a biocide in air fresheners and deodorants. |
| Use | used as a substitute for standard solutions of iodine and hypochlorite in volumetric analysis, for the determination of bromate and halogen, for the determination of iodide, thallium and tin, used as reagents for the supply of chlorine, disinfectants, medicines (antiseptics). |
Last Update：2024-04-09 20:52:54
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